The trade-off is performance. Every syscall goes through user-space interception, which adds overhead. I/O-heavy workloads feel this the most. For short-lived code execution like scripts and tests, it is usually fine, but for sustained high-throughput I/O, it can matter.
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While I was writing this blog post, Vercel's Malte Ubl published their own blog post describing some research work Vercel has been doing around improving the performance of Node.js' Web streams implementation. In that post they discuss the same fundamental performance optimization problem that every implementation of Web streams face: