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In 2006, 454 collaborated with Swedish paleogeneticist Svante Pääbo to sequence the first million base pairs of the Neanderthal genome; the project would be completed four years later, albeit with some help from Illumina sequencing. Illumina and other subsequent NGS technologies rendered pyrosequencing non-competitive, and in 2013, 454 was shut down by Roche, which had acquired it six years earlier. The technology is still used today for some applications, but most importantly, it was the first commercially viable alternative to Sanger sequencing, and the first sequencing method that could be fully automated because it didn’t rely on gels or other tedious steps.，详情可参考爱思助手下载最新版本
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这一次，美光率先采用单片式32Gb(8GB) LPDDR5X内存颗粒，将总容量做到了256GB，对比标准的RDIMM内存条容量增大了1/3，体积缩小了2/3％，功耗也降低了2/3。